CREB1
E1551060
UNEXPLORED
CREB1 is a cellular transcription factor that binds cAMP response elements in DNA to regulate gene expression involved in cell survival, proliferation, and differentiation.
All labels observed (1)
| Label | Occurrences |
|---|---|
| CREB1 canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T22693520 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CREB1 Context triple: [EWSR1, formsFusionWith, CREB1]
-
A.
NEUROD1 transcription factor
NEUROD1 transcription factor is a basic helix-loop-helix (bHLH) transcription factor crucial for neuronal differentiation and pancreatic beta-cell development, where it helps control insulin gene expression.
-
B.
c-Myc
c-Myc is a proto-oncogene transcription factor that regulates cell growth, proliferation, and metabolism and is frequently dysregulated in cancer.
-
C.
Sox2
Sox2 is a key transcription factor that maintains stem cell pluripotency and self-renewal and is widely used in cellular reprogramming.
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D.
CaMKII
CaMKII (Calcium/calmodulin-dependent protein kinase II) is a key serine/threonine kinase in neurons that decodes calcium signals to regulate synaptic plasticity, learning, and memory.
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E.
TRKB
TRKB is a receptor tyrosine kinase encoded by the NTRK2 gene that plays a key role in neurotrophin signaling and neuronal development.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CREB1 Target entity description: CREB1 is a cellular transcription factor that binds cAMP response elements in DNA to regulate gene expression involved in cell survival, proliferation, and differentiation.
-
A.
NEUROD1 transcription factor
NEUROD1 transcription factor is a basic helix-loop-helix (bHLH) transcription factor crucial for neuronal differentiation and pancreatic beta-cell development, where it helps control insulin gene expression.
-
B.
c-Myc
c-Myc is a proto-oncogene transcription factor that regulates cell growth, proliferation, and metabolism and is frequently dysregulated in cancer.
-
C.
Sox2
Sox2 is a key transcription factor that maintains stem cell pluripotency and self-renewal and is widely used in cellular reprogramming.
-
D.
CaMKII
CaMKII (Calcium/calmodulin-dependent protein kinase II) is a key serine/threonine kinase in neurons that decodes calcium signals to regulate synaptic plasticity, learning, and memory.
-
E.
TRKB
TRKB is a receptor tyrosine kinase encoded by the NTRK2 gene that plays a key role in neurotrophin signaling and neuronal development.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.