RBL2
E1550407
UNEXPLORED
RBL2 is a tumor suppressor protein of the retinoblastoma family that regulates cell cycle progression by controlling E2F transcription factor activity.
All labels observed (1)
| Label | Occurrences |
|---|---|
| RBL2 canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T22690292 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: RBL2 Context triple: [CDK4, substrate, RBL2]
-
A.
RBL1
RBL1 is a tumor suppressor protein of the retinoblastoma family that regulates cell cycle progression by controlling E2F transcription factor activity.
-
B.
c-Myc
c-Myc is a proto-oncogene transcription factor that regulates cell growth, proliferation, and metabolism and is frequently dysregulated in cancer.
-
C.
RB1
RB1 is a tumor suppressor protein that regulates the cell cycle by controlling the transition from G1 to S phase and is frequently inactivated in human cancers.
-
D.
Clb3
Clb3 is a B-type cyclin in budding yeast that partners with the Cdc28 kinase to regulate progression through the cell cycle, particularly during S and G2 phases.
-
E.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: RBL2 Target entity description: RBL2 is a tumor suppressor protein of the retinoblastoma family that regulates cell cycle progression by controlling E2F transcription factor activity.
-
A.
RBL1
RBL1 is a tumor suppressor protein of the retinoblastoma family that regulates cell cycle progression by controlling E2F transcription factor activity.
-
B.
c-Myc
c-Myc is a proto-oncogene transcription factor that regulates cell growth, proliferation, and metabolism and is frequently dysregulated in cancer.
-
C.
RB1
RB1 is a tumor suppressor protein that regulates the cell cycle by controlling the transition from G1 to S phase and is frequently inactivated in human cancers.
-
D.
Clb3
Clb3 is a B-type cyclin in budding yeast that partners with the Cdc28 kinase to regulate progression through the cell cycle, particularly during S and G2 phases.
-
E.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.