RET kinase
E1549328
UNEXPLORED
RET kinase is a receptor tyrosine kinase involved in cell growth and differentiation whose activating alterations drive several cancers, making it an important therapeutic target.
All labels observed (1)
| Label | Occurrences |
|---|---|
| RET kinase canonical | 3 |
How this entity was disambiguated
This entity first appeared as the object of triple T22690408 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: RET kinase Context triple: [selpercatinib, target, RET kinase]
-
A.
ERK
ERK is the abbreviation for the Evangelical Reformed Church, a Protestant regional church within the Reformed tradition.
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B.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
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C.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
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D.
CaMKII
CaMKII (Calcium/calmodulin-dependent protein kinase II) is a key serine/threonine kinase in neurons that decodes calcium signals to regulate synaptic plasticity, learning, and memory.
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E.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: RET kinase Target entity description: RET kinase is a receptor tyrosine kinase involved in cell growth and differentiation whose activating alterations drive several cancers, making it an important therapeutic target.
-
A.
ERK
ERK is the abbreviation for the Evangelical Reformed Church, a Protestant regional church within the Reformed tradition.
-
B.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
-
C.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
D.
CaMKII
CaMKII (Calcium/calmodulin-dependent protein kinase II) is a key serine/threonine kinase in neurons that decodes calcium signals to regulate synaptic plasticity, learning, and memory.
-
E.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
- F. None of above. chosen
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.