CDKN2A (p16INK4A)
E1549320
UNEXPLORED
CDKN2A (p16INK4A) is a tumor suppressor gene encoding a cyclin-dependent kinase inhibitor that controls cell cycle progression and is frequently inactivated in human cancers.
All labels observed (3)
| Label | Occurrences |
|---|---|
| CDKN2A | 1 |
| CDKN2A (p16INK4A) canonical | 1 |
| p16INK4A | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T22690296 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CDKN2A (p16INK4A) Context triple: [CDK4, regulatedBy, CDKN2A (p16INK4A)]
-
A.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
B.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
-
C.
Cdh1
Cdh1 is a regulatory protein that activates the anaphase-promoting complex/cyclosome (APC/C) to control mitotic exit and G1 phase progression in the cell cycle.
-
D.
c-Myc
c-Myc is a proto-oncogene transcription factor that regulates cell growth, proliferation, and metabolism and is frequently dysregulated in cancer.
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E.
PTEN
PTEN is a tumor suppressor gene encoding a phosphatase that negatively regulates the PI3K/AKT signaling pathway and is frequently mutated in various human cancers.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CDKN2A (p16INK4A) Target entity description: CDKN2A (p16INK4A) is a tumor suppressor gene encoding a cyclin-dependent kinase inhibitor that controls cell cycle progression and is frequently inactivated in human cancers.
-
A.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
B.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
-
C.
Cdh1
Cdh1 is a regulatory protein that activates the anaphase-promoting complex/cyclosome (APC/C) to control mitotic exit and G1 phase progression in the cell cycle.
-
D.
c-Myc
c-Myc is a proto-oncogene transcription factor that regulates cell growth, proliferation, and metabolism and is frequently dysregulated in cancer.
-
E.
PTEN
PTEN is a tumor suppressor gene encoding a phosphatase that negatively regulates the PI3K/AKT signaling pathway and is frequently mutated in various human cancers.
- F. None of above. chosen
Referenced by (3)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: CDKN2A (p16INK4A)
linked to: CDKN2A (p16INK4A)