PTEN
E1436032
UNEXPLORED
PTEN is a tumor suppressor gene encoding a phosphatase that negatively regulates the PI3K/AKT signaling pathway and is frequently mutated in various human cancers.
All labels observed (2)
| Label | Occurrences |
|---|---|
| PTEN canonical | 3 |
| PTEN phosphatase | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T20517943 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: PTEN Context triple: [Alfred Bester, network, PTEN]
-
A.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
B.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
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C.
PTPN
PTPN is the ICAO airport code for Pohnpei International Airport in the Federated States of Micronesia.
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D.
BRCA2 gene
The BRCA2 gene is a human tumor suppressor gene whose mutations are strongly associated with an increased risk of breast, ovarian, and other cancers.
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E.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: PTEN Target entity description: PTEN is a tumor suppressor gene encoding a phosphatase that negatively regulates the PI3K/AKT signaling pathway and is frequently mutated in various human cancers.
-
A.
CDK4
CDK4 is a cyclin-dependent kinase that regulates cell cycle progression and is a key therapeutic target in certain cancers.
-
B.
CDK6
CDK6 is a cyclin-dependent kinase that regulates cell cycle progression and is a key target in certain cancer therapies.
-
C.
PTPN
PTPN is the ICAO airport code for Pohnpei International Airport in the Federated States of Micronesia.
-
D.
BRCA2 gene
The BRCA2 gene is a human tumor suppressor gene whose mutations are strongly associated with an increased risk of breast, ovarian, and other cancers.
-
E.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
- F. None of above. chosen
Referenced by (4)
Full triples — surface form annotated when it differs from this entity's canonical label.
linked to: PTEN