CaMKII
E1405311
UNEXPLORED
CaMKII (Calcium/calmodulin-dependent protein kinase II) is a key serine/threonine kinase in neurons that decodes calcium signals to regulate synaptic plasticity, learning, and memory.
All labels observed (1)
| Label | Occurrences |
|---|---|
| CaMKII canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T19992850 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CaMKII Context triple: [NMDA receptor, interactsWith, CaMKII]
-
A.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
-
B.
adenylyl cyclase
Adenylyl cyclase is a membrane-bound enzyme that converts ATP to the second messenger cyclic AMP, playing a central role in many signal transduction pathways.
-
C.
PKC
PKC is a leading international cryptography conference focused on public-key cryptography research and advancements.
-
D.
PKC
PKC is the IATA airport code for Petropavlovsk-Kamchatsky Airport, a major air gateway to Russia’s Kamchatka Peninsula.
-
E.
AMPA receptors
AMPA receptors are fast-acting ionotropic glutamate receptors in the brain that mediate most rapid excitatory synaptic transmission and play key roles in synaptic plasticity and learning.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CaMKII Target entity description: CaMKII (Calcium/calmodulin-dependent protein kinase II) is a key serine/threonine kinase in neurons that decodes calcium signals to regulate synaptic plasticity, learning, and memory.
-
A.
PLCγ2
PLCγ2 is a phospholipase C isoform that functions as a key signaling enzyme in immune cells, mediating receptor-induced calcium mobilization and downstream activation pathways.
-
B.
adenylyl cyclase
Adenylyl cyclase is a membrane-bound enzyme that converts ATP to the second messenger cyclic AMP, playing a central role in many signal transduction pathways.
-
C.
PKC
PKC is a leading international cryptography conference focused on public-key cryptography research and advancements.
-
D.
PKC
PKC is the IATA airport code for Petropavlovsk-Kamchatsky Airport, a major air gateway to Russia’s Kamchatka Peninsula.
-
E.
AMPA receptors
AMPA receptors are fast-acting ionotropic glutamate receptors in the brain that mediate most rapid excitatory synaptic transmission and play key roles in synaptic plasticity and learning.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.