insulin signaling pathway
E1365589
UNEXPLORED
The insulin signaling pathway is a cellular communication network through which insulin regulates glucose uptake, metabolism, and growth-related processes in target tissues.
All labels observed (1)
| Label | Occurrences |
|---|---|
| insulin signaling pathway canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T19245362 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: insulin signaling pathway Context triple: [INS gene, memberOfPathway, insulin signaling pathway]
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A.
PI3K-AKT signaling pathway
The PI3K-AKT signaling pathway is a key intracellular cascade that regulates cell growth, survival, metabolism, and proliferation, and is frequently dysregulated in cancer.
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B.
MAPK signaling pathway
The MAPK signaling pathway is a key intracellular cascade that transmits growth and survival signals from cell surface receptors to the nucleus, regulating processes such as proliferation, differentiation, and apoptosis.
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C.
insulin
Insulin is a peptide hormone produced by the pancreas that regulates blood glucose levels and is essential in the treatment of diabetes.
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D.
JAK-STAT signaling pathway
The JAK-STAT signaling pathway is a key intracellular cascade that transmits signals from cell-surface receptors to the nucleus to regulate gene expression involved in cell growth, differentiation, immune function, and survival.
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E.
Preiss–Handler pathway
The Preiss–Handler pathway is a metabolic route in which cells convert nicotinic acid (niacin) into NAD+, a vital coenzyme involved in redox reactions and energy metabolism.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: insulin signaling pathway Target entity description: The insulin signaling pathway is a cellular communication network through which insulin regulates glucose uptake, metabolism, and growth-related processes in target tissues.
-
A.
PI3K-AKT signaling pathway
The PI3K-AKT signaling pathway is a key intracellular cascade that regulates cell growth, survival, metabolism, and proliferation, and is frequently dysregulated in cancer.
-
B.
MAPK signaling pathway
The MAPK signaling pathway is a key intracellular cascade that transmits growth and survival signals from cell surface receptors to the nucleus, regulating processes such as proliferation, differentiation, and apoptosis.
-
C.
insulin
Insulin is a peptide hormone produced by the pancreas that regulates blood glucose levels and is essential in the treatment of diabetes.
-
D.
JAK-STAT signaling pathway
The JAK-STAT signaling pathway is a key intracellular cascade that transmits signals from cell-surface receptors to the nucleus to regulate gene expression involved in cell growth, differentiation, immune function, and survival.
-
E.
Preiss–Handler pathway
The Preiss–Handler pathway is a metabolic route in which cells convert nicotinic acid (niacin) into NAD+, a vital coenzyme involved in redox reactions and energy metabolism.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject linked to:
INS gene in humans