NEUROD1 transcription factor
E1365588
UNEXPLORED
NEUROD1 transcription factor is a basic helix-loop-helix (bHLH) transcription factor crucial for neuronal differentiation and pancreatic beta-cell development, where it helps control insulin gene expression.
All labels observed (1)
| Label | Occurrences |
|---|---|
| NEUROD1 transcription factor canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T19245358 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: NEUROD1 transcription factor Context triple: [INS gene, regulatedBy, NEUROD1 transcription factor]
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A.
Sox2
Sox2 is a key transcription factor that maintains stem cell pluripotency and self-renewal and is widely used in cellular reprogramming.
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B.
Notch intracellular domain
The Notch intracellular domain is the cleaved, cytoplasmic fragment of the Notch receptor that translocates to the nucleus to regulate gene transcription in the Notch signaling pathway.
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C.
Wnt1
Wnt1 is a highly conserved signaling protein in the Wnt family that plays a crucial role in embryonic development, cell fate determination, and oncogenesis in vertebrates.
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D.
c-Myc
c-Myc is a proto-oncogene transcription factor that regulates cell growth, proliferation, and metabolism and is frequently dysregulated in cancer.
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E.
TARDBP
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: NEUROD1 transcription factor Target entity description: NEUROD1 transcription factor is a basic helix-loop-helix (bHLH) transcription factor crucial for neuronal differentiation and pancreatic beta-cell development, where it helps control insulin gene expression.
-
A.
Sox2
Sox2 is a key transcription factor that maintains stem cell pluripotency and self-renewal and is widely used in cellular reprogramming.
-
B.
Notch intracellular domain
The Notch intracellular domain is the cleaved, cytoplasmic fragment of the Notch receptor that translocates to the nucleus to regulate gene transcription in the Notch signaling pathway.
-
C.
Wnt1
Wnt1 is a highly conserved signaling protein in the Wnt family that plays a crucial role in embryonic development, cell fate determination, and oncogenesis in vertebrates.
-
D.
c-Myc
c-Myc is a proto-oncogene transcription factor that regulates cell growth, proliferation, and metabolism and is frequently dysregulated in cancer.
-
E.
TARDBP
TARDBP is a gene encoding the TDP-43 protein, a DNA/RNA-binding protein whose abnormal aggregation is a key pathological feature in amyotrophic lateral sclerosis and related neurodegenerative diseases.
- F. None of above. chosen
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.
subject linked to:
INS gene in humans