CRISPR-Cas systems
E1153658
UNEXPLORED
CRISPR-Cas systems are adaptive immune mechanisms found in bacteria and archaea that have been repurposed as powerful, programmable tools for genome editing and gene regulation.
All labels observed (2)
| Label | Occurrences |
|---|---|
| CRISPR-Cas systems canonical | 1 |
| CRISPR-Cas9 | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T15360869 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: CRISPR-Cas systems Context triple: [Samuel H. Sternberg, fieldOfWork, CRISPR-Cas systems]
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A.
CRISPR-Cas9 gene-editing technology
CRISPR-Cas9 gene-editing technology is a revolutionary molecular tool that allows scientists to precisely modify DNA within living organisms, transforming research, medicine, and biotechnology.
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B.
Cpf1 (Cas12a)
Cpf1 (Cas12a) is a CRISPR-associated endonuclease used for genome editing that recognizes different DNA target sequences and creates staggered cuts, offering distinct advantages and applications compared to Cas9.
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C.
The Evolution of Genetic Systems
The Evolution of Genetic Systems is a seminal scientific work by cytogeneticist C. D. Darlington that explores how chromosomes and genetic mechanisms change and diversify over evolutionary time.
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D.
SaCas9
SaCas9 is a compact Cas9 nuclease derived from Staphylococcus aureus that enables CRISPR-based genome editing, particularly useful where smaller delivery vectors such as AAV are required.
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E.
A Genetic Switch: Phage Lambda and Higher Organisms
"A Genetic Switch: Phage Lambda and Higher Organisms" is a seminal molecular biology book that explains how gene regulation in bacteriophage lambda illuminates fundamental mechanisms of genetic control in more complex organisms.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: CRISPR-Cas systems Target entity description: CRISPR-Cas systems are adaptive immune mechanisms found in bacteria and archaea that have been repurposed as powerful, programmable tools for genome editing and gene regulation.
-
A.
CRISPR-Cas9 gene-editing technology
CRISPR-Cas9 gene-editing technology is a revolutionary molecular tool that allows scientists to precisely modify DNA within living organisms, transforming research, medicine, and biotechnology.
-
B.
Cpf1 (Cas12a)
Cpf1 (Cas12a) is a CRISPR-associated endonuclease used for genome editing that recognizes different DNA target sequences and creates staggered cuts, offering distinct advantages and applications compared to Cas9.
-
C.
The Evolution of Genetic Systems
The Evolution of Genetic Systems is a seminal scientific work by cytogeneticist C. D. Darlington that explores how chromosomes and genetic mechanisms change and diversify over evolutionary time.
-
D.
SaCas9
SaCas9 is a compact Cas9 nuclease derived from Staphylococcus aureus that enables CRISPR-based genome editing, particularly useful where smaller delivery vectors such as AAV are required.
-
E.
A Genetic Switch: Phage Lambda and Higher Organisms
"A Genetic Switch: Phage Lambda and Higher Organisms" is a seminal molecular biology book that explains how gene regulation in bacteriophage lambda illuminates fundamental mechanisms of genetic control in more complex organisms.
- F. None of above. chosen
Referenced by (2)
Full triples — surface form annotated when it differs from this entity's canonical label.
A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution
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topic
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CRISPR-Cas9
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linked to: CRISPR-Cas systems