picrotoxin
E1046866
Picrotoxin is a highly toxic plant-derived compound that acts as a noncompetitive antagonist of GABA_A receptors, historically used as a stimulant and experimental convulsant in neuroscience research.
All labels observed (1)
| Label | Occurrences |
|---|---|
| picrotoxin canonical | 1 |
How this entity was disambiguated
This entity first appeared as the object of triple T13563142 — resolving that mention is where its identity was fixed. The disambiguator weighed these candidate entities and picked the highlighted one (or “None”, minting a new entity). This is how homonymy is resolved: the same surface form can point to different entities.
NED1
Entity disambiguation (via context triple)
gpt-5-mini-2025-08-07
Target entity: picrotoxin Context triple: [Anamirta, containsChemicalCompound, picrotoxin]
-
A.
D-Tox
D-Tox is a 2002 American psychological thriller film starring Sylvester Stallone as an FBI agent confronting a serial killer inside a remote rehabilitation facility for traumatized law enforcement officers.
-
B.
Halahala poison
Halahala poison is the deadly, primordial toxin that emerged during the Hindu mythological churning of the ocean and was consumed by Shiva to protect the universe.
-
C.
Xyloto
Xyloto is the fictional protagonist featured in Coldplay’s concept album and related media project "Mylo Xyloto."
-
D.
Reitox
Reitox is the European information network on drugs and drug addiction, linking national focal points to support the EU’s monitoring and analysis of drug-related issues.
-
E.
Toxeus
Toxeus is a figure in Greek mythology known primarily as one of the sons of Althaea and Oeneus, often mentioned in the context of the Calydonian royal family and its associated legends.
- F. None of above. chosen
- G. Unsure - the case is ambiguous/there is not enough information to decide.
NED2
Entity disambiguation (via description)
gpt-5-mini-2025-08-07
Target entity: picrotoxin Target entity description: Picrotoxin is a highly toxic plant-derived compound that acts as a noncompetitive antagonist of GABA_A receptors, historically used as a stimulant and experimental convulsant in neuroscience research.
-
A.
D-Tox
D-Tox is a 2002 American psychological thriller film starring Sylvester Stallone as an FBI agent confronting a serial killer inside a remote rehabilitation facility for traumatized law enforcement officers.
-
B.
Halahala poison
Halahala poison is the deadly, primordial toxin that emerged during the Hindu mythological churning of the ocean and was consumed by Shiva to protect the universe.
-
C.
Xyloto
Xyloto is the fictional protagonist featured in Coldplay’s concept album and related media project "Mylo Xyloto."
-
D.
Reitox
Reitox is the European information network on drugs and drug addiction, linking national focal points to support the EU’s monitoring and analysis of drug-related issues.
-
E.
Toxeus
Toxeus is a figure in Greek mythology known primarily as one of the sons of Althaea and Oeneus, often mentioned in the context of the Calydonian royal family and its associated legends.
- F. None of above. chosen
Statements (47)
| Predicate | Object |
|---|---|
| instanceOf |
GABA_A receptor antagonist
ⓘ
chemical compound ⓘ neurotoxin ⓘ plant-derived toxin ⓘ |
| affectsOrganSystem |
cardiovascular system
ⓘ
central nervous system ⓘ respiratory system ⓘ |
| antagonizes | GABA-mediated inhibitory neurotransmission ⓘ |
| bindingSite | GABA_A receptor chloride channel pore ⓘ |
| effectOnIonFlux | inhibits chloride influx through GABA_A receptors ⓘ |
| hasChemicalNature | sesquiterpene ⓘ |
| hasComponent |
picrotin
ⓘ
picrotoxinin ⓘ |
| hasOrigin |
Anamirta cocculus
ⓘ
Cocculus indicus seeds ⓘ |
| hasPharmacologicalAction |
central nervous system stimulant
ⓘ
convulsant ⓘ noncompetitive GABA_A receptor antagonist ⓘ |
| hasPhysiologicalEffect |
causes convulsions
ⓘ
induces neuronal hyperexcitability ⓘ induces seizures at sufficient doses ⓘ |
| hasTaste | bitter ⓘ |
| hasToxicEffect |
cardiovascular disturbances
ⓘ
clonic and tonic-clonic seizures ⓘ nausea and vomiting ⓘ respiratory failure at high doses ⓘ tremors ⓘ |
| historicalUse |
central nervous system stimulant
ⓘ
experimental convulsant in neuroscience research ⓘ respiratory stimulant ⓘ |
| isHighlyToxic | true ⓘ |
| isNot | competitive GABA_A receptor antagonist ⓘ |
| mechanismOfAction | blocks GABA_A receptor-associated chloride channels ⓘ |
| modulatesNeurotransmission | GABAergic neurotransmission ⓘ |
| physicalStateAtRoomTemperature | solid ⓘ |
| requiresHandlingPrecautions | true ⓘ |
| riskClassification | highly toxic substance ⓘ |
| routeOfExposure |
intravenous
ⓘ
oral ⓘ |
| solubility |
poorly soluble in water
ⓘ
soluble in organic solvents ⓘ |
| targetsReceptor | GABA_A receptor ⓘ |
| usedAs | pharmacological tool compound ⓘ |
| usedIn |
GABA_A receptor pharmacology experiments
ⓘ
epilepsy models ⓘ neuroscience research ⓘ studies of inhibitory synaptic transmission ⓘ |
How these facts were elicited
The pipeline generated the facts above by prompting gpt-5.1 with this entity's name + description and the instruction below.
Instruction
You are a knowledge base construction expert. Given a subject entity and a description of it, return factual statements that you know for the subject as a JSON list of dictionaries(triples), where keys must be "subject", "predicate" and "object". The number of facts may be very high, between 25 to 50 or more, for very popular subjects. For less popular subjects, the number of facts can be very low, like 5 or 10. # Requirements - If you don't know the subject at all, return an empty list. - If the subject is not a named entity, return an empty list. - Include at least one triple where predicate is "instanceOf". - Do not get too wordy. - Separate several objects into multiple triples with one object.
Input
Subject: picrotoxin Description of subject: Picrotoxin is a highly toxic plant-derived compound that acts as a noncompetitive antagonist of GABA_A receptors, historically used as a stimulant and experimental convulsant in neuroscience research.
Referenced by (1)
Full triples — surface form annotated when it differs from this entity's canonical label.